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further information

The Sample Treatment Accessory produces homogeneous sample-matrix co-crystal formation by employing the vacuum-induced crystallization technique. Vacuum-induced crystallization is a rapid, turbulent process in which many closely spaced nucleation sites are formed. Crystallization continues as the nucleation sites grow outwards to create a continuous sheet. Using the Sample Treatment Accessory, you can visually inspect the loaded sample through a 7 x magnification ocular while vacuum is applied. Precise, real-time control of applied vacuum is provided, producing excellent sample-matrix co-crystallization. Vacuum formed sample-matrix co-crystals are smaller and more regularly deposited on sample probe surfaces than their atmospheric or heat dried counter-parts. Finding quality crystals or ”sweet spots" is simple, eliminating the need for expensive, complicated sample viewing accessories.

This procedure is very simple, and typically takes just a few minutes. The process begins by dissolving samples in an appropriate solvent. For MALDI, samples are mixed with a selected matrix prior to analysis. About one microliter of the matrix-sample mixture is deposited on a single position (or mesa) of the precision-machined multi-position sample probe. The droplet is immediately vacuum dried, using the Sample Treatment Accessory, forming an evenly distributed crystalline or film layer. After the sample probe has been introduced into the vacuum chamber the data aquisition begins with firing of the nitrogen laser. A clock starting pulse is split off from the laser light just prior to the beam striking the sample. Desorption and ionization occur followed by acceleration. Solutes of different m/z achieve different velocities and are detected as time resolved signals. Flight time is converted to m/z and solute molecular weights are determined.

GSG has incorporated a variety of design features which ensures rapid, sensitive and accurate molecular weight determination even at low femtomole levels of sample. The GSG future can also be used as a tool for combinatorial chemistry, to monitor the rate and progress of chemical or enzymatic reactions, or combine it with specific enyzmatic activities to provide biopolymer structural information.
The GSG future mass spectrometer utilizes a dual micro-channel plate array detector with a proprietary secondary ion generator, which greatly increases the detector conversion efficiency and the sensitivity for large ions. This easy-to-use system facilitates fully automated operation supported by an intuitive Microsoft Windows TM based Software program which makes mass spectral data collection simple by using complete, single point instrument control. The GSG future system software makes any operator more productive by employing two different user interface modes ergonomically matched to their requirements and skill. The system can be operated with minimal knowledge. The Standard Interface mode provides access to all features and gives complete flexibility and system control.

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