| Desorption
Electrospray Ionization (DESI) is carried out by directing charged
droplets produced from a pneumatically-assisted electrospray onto
a surface to be analyzed at atmospheric conditions. Ions of chemical
species present on the surface are produced through the interaction
of the charged droplets and the sample. The resulting mass spectra
are similar to ESI Mass Spectra. The composition of the spray solvent,
the gas flow rate, the magnitude of the applied voltage, the impact
angle, as well as, various distances in aligning the spray with respect
to the surface and inlet of the mass spectrometer are variables that
can be studied to achieve optimal performance. |
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The Omni Spray Ion Sources are compatible for almost all commercial
available mass spectrometers. +++
The benefits of Desorption Electrospray
Ionization include the following:
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• DESI is a DIRECT sampling method
that requires absolutely no sample preparation
• DESI operates in the atmosphere under ambient
conditions
• DESI is a "sensitive" and "gentle"
ionization method for the analysis or interrogation of all
types of surfaces
• DESI produces electrospray-like spectra
• DESI is effective for both organic and biological
compounds
• DESI is effective for polar and non-polar molecules
• DESI allows for in situ analysis of biological
tissues and other fragile surfaces
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Accessories:
2-D FireFly Software: Extracts and builds data sets from
proprietary data systems using data converstion algorithms into
file formats compatible with BioMAP, a third party image viualization
and processing software program available for free on the Internet.
Omni Slide Hydrophobic Arrays: A line of DESI substrates
for reproducible dample spotting an improved signal stability in
high-throughput and quantitative studies.
Control Software: 1-D and 2-D Automated Models for X and
Y axes movement of sample stage uses control software that:
- Runs independent of MS instrument control software
- Triggers MS to synchronize data acquisition
- Integrated video capture to view sample analysis location in
real time
- Includes 5 automated motion profiles (Manual control, start
point constant velocity, Point to point - constant velocity, Point
to point - dwell, Point to point - oscillation
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further information 
Applications:
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Life Sciences
The Omni Spray DESI Ion Source is applied to life sciences
research with its ability to simplify the bioanalytical
workflow by enabling direct sampling of complex matrices,
such as intact tissue or blood, for biomarker profiling.
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Pharmaceutical
The Omni Spray DESI Ion Source is applicable in the pharmaceutical
industry by enabling direct measurements of tablets to identify
counterfeit materials or for determining drug and metabolite
concentrations in biological fluids or determining the spatial
distribution of a drug, its metabolites, or endogenous components
in intact tissue sections.
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Forensics
The Omni Spray DESI Ion Source provides direct measurements
of samples, such as explosives residue on bomb fragments
and determines the concentrations of narcotics in urine.
Additionally, the Source can create a chemical image of
a latent fingerprint.
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Materials
The Omni Spray DESI Ion Source provides an analysis of materials,
such as plastics or glass, for identifying potential surface
contaminants or by-products from the manufacturing process.
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Food
The Omni Spray DESI Ion Source enables rapid measurements
of unprocessed samples such as food or natural products.
The direct identification of toxic contaminants in dry foods,
leachable materials, or profiling natural sweeteners in
Stevia Rebaudiana varietal are just a few examples.
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Environmental
The Omni Spray DESI Ion Source is right for Environmental
sampling whether analyzing pesticide residue, natural products,
or detecting chemical contamination in situ with minimal
sample preparation.
- Security
The Omni Spray DESI Ion Source has the ability to detect chemical
warfare agents, hazardous chemicals, and explosives rapidly
in complex environments
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